Open AccessWrong‐Way Chloride Transport: Is It a Treatable Cause of Some Intractable Seizures?
Author(s) -
Staley Kevin J.
Publication year - 2006
Publication title -
epilepsy currents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 22
eISSN - 1535-7511
pISSN - 1535-7597
DOI - 10.1111/j.1535-7511.2006.00119.x
Subject(s) - anticonvulsant , medicine , neuroscience , neurotransmitter , intractable epilepsy , epilepsy , pharmacology , anesthesia , central nervous system , psychiatry , psychology
Despite decades of research and a half dozen new anticonvulsant agents, some types of seizures are as untreatable now as they were in the days of bromides. These treatment‐resistant seizures suggest that some of the assumptions about anticonvulsant mechanisms may need revision. This review will focus on one of the bedrock assumptions of epileptology that the neurotransmitter GABA inhibits neuronal activity, and therefore, agents that increase GABA activity should increase inhibition and consequently decrease the abnormal neuronal activity that occurs during a seizure.