Open AccessHow to Explain Multidrug Resistance in Epilepsy?
Author(s) -
Löscher Wolfgang
Publication year - 2005
Publication title -
epilepsy currents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 22
eISSN - 1535-7511
pISSN - 1535-7597
DOI - 10.1111/j.1535-7511.2005.05311.x
Subject(s) - epilepsy , antiepileptic drug , mechanism (biology) , drug resistance , multiple drug resistance , efflux , drug , medicine , intractable epilepsy , neuroscience , pharmacology , bioinformatics , psychology , psychiatry , biology , genetics , philosophy , epistemology
Despite advancements in antiepileptic therapy, about one third of people with epilepsy will remain intractable to medication. The initial response to antiepileptic drug therapy is highly predictive of long‐term outcome. However, the mechanisms of medical intractability of epilepsy are only incompletely understood. Current interest is focused on two hypotheses: overexpression of drug efflux transporters and alterations in drug targets in the brain, with the most relevant causative mechanism(s) still to be elucidated.