Open AccessThe Role of the Subiculum in Epilepsy and Epileptogenesis
Author(s) -
Stafstrom Carl E.
Publication year - 2005
Publication title -
epilepsy currents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 22
eISSN - 1535-7511
pISSN - 1535-7597
DOI - 10.1111/j.1535-7511.2005.00049.x
Subject(s) - subiculum , epileptogenesis , epilepsy , neuroscience , hippocampus , afferent , medicine , mesial temporal lobe epilepsy , temporal lobe , clinical neurology , psychology , dentate gyrus
The subiculum is the first output structure distal to the hippocampus, abutting subfield CA1. As such, the subiculum receives afferent input from the hippocampus. Accumulating clinical and experimental evidence suggests that the subiculum plays an important role in the initiation and maintenance of epileptic discharges in temporal lobe epilepsy. This review discusses the anatomy and physiology of the subiculum and examines its participation in epilepsy and epileptogenesis.