Open AccessCytokine Polymorphism in Patients with Migraine: Some Suggestive Clues of Migraine and Inflammation
Author(s) -
Yılmaz Ibrahim Arda,
Özge Aynur,
Erdal Mehmet Emin,
Edgünlü Tuba Gökdoğan,
Çakmak Sema Erol,
Yalın Osman Özgür
Publication year - 2010
Publication title -
pain medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.893
H-Index - 97
eISSN - 1526-4637
pISSN - 1526-2375
DOI - 10.1111/j.1526-4637.2009.00791.x
Subject(s) - migraine , aura , allele , genotype , medicine , allele frequency , tumor necrosis factor alpha , migraine with aura , polymorphism (computer science) , interleukin 6 , gene polymorphism , immunology , gastroenterology , cytokine , endocrinology , gene , biology , genetics
Objective. There are contrasting results obtained in migraineurs concerning the levels and the role of both pro‐inflammatory and anti‐inflammatory cytokines. In this study, the association of the occurrence and clinical characteristics of migraine with the polymorphisms of tumor necrosis factor α (TNF‐α) −308 G/A (rs1800629), interleukin‐1α (IL‐1α) +4845 G/T (rs17561), IL‐1β+3953 C/T (rs1143634) and interleukin‐1 receptor antagonist variable number tandem repeat (IL‐1RA VNTR) genes were studied. We also investigated the genetic linkage between these genes. Design, Setting, Patients. Sixty‐seven patients with migraine without aura (MwoA) and 96 unrelated, age‐ and sex‐matched migraine‐free, healthy control subjects from the same geographic area were investigated. Results. We observed significant differences in the genotypic distribution of the TNF‐α−308 G/A and IL‐1β+3953 C/T polymorphism for migraineurs compared with controls ( P = 0.004). Frequency of the TNF‐α−308 GG genotype was higher in the control group than MwoA group (82.1% vs 55.2%). Differences in the distribution of the allele frequencies were also observed, being the TNF‐α−308 G allele overrepresented in control group and TNF‐α−308 A allele in MwoA group. In addition, there was a significant increase of the IL‐1β+3953 T allele in MwoA cases compared with controls ( P = 0.004). Conclusions. In conclusion, the present results indicate the possible contribution of TNF‐α and IL‐1β gene polymorphisms to migraine headache generation in MwoA patients.