Open AccessWithdrawal Symptoms from Transdermal Fentanyl (TDF) after an Allogeneic Peripheral Blood Stem Cell Transplant (PBSCT)
Author(s) -
Tsutsumi Yutaka,
Kanamori Hiroe,
Tanaka Junji,
Asaka Masahiro,
Imamura Masahiro,
Masauzi Nobuo
Publication year - 2006
Publication title -
pain medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.893
H-Index - 97
eISSN - 1526-4637
pISSN - 1526-2375
DOI - 10.1111/j.1526-4637.2006.00107.x
Subject(s) - medicine , fentanyl , transdermal , peripheral blood , anesthesia , peripheral , stem cell , cyp3a4 , surgery , pharmacology , biology , genetics , cytochrome p450 , metabolism
A 47‐year‐old woman who underwent allogenic peripheral blood stem cell transplant developed withdrawal symptoms soon after Fentanyl 25 mcg/h patch was stopped, which has not been reported at this dose. Possible causes, such as the inhibition of CYP3A4 induced by cyclosporine causing elevations of serum fentanyl, are discussed.