Open AccessTopiramate for Phantom Limb Pain: A Time‐Series Analysis
Author(s) -
Harden R. Norman,
Houle Tim T.,
Remble Thomas A.,
Lin Wendy,
Wang Kenten,
Saltz Samuel
Publication year - 2005
Publication title -
pain medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.893
H-Index - 97
eISSN - 1526-4637
pISSN - 1526-2375
DOI - 10.1111/j.1526-4637.2005.00060.x
Subject(s) - topiramate , phantom limb pain , medicine , phantom limb , phantom pain , neuropathic pain , anesthesia , imaging phantom , physical medicine and rehabilitation , physical therapy , amputation , surgery , nuclear medicine , epilepsy , psychiatry
There is growing evidence of topiramate's efficacy in treating neuropathic pain. This article reports a detailed analysis of the response of four amputee subjects with phantom limb pain. Individual time‐series analyses revealed that three out of four amputee participants receiving topiramate had statistically significant decreases in pain, with the peak effect noted at 800 mg daily. This analysis supports a hypothesis that topiramate may be effective in reducing phantom limb pain, and suggests a definitive study is indicated.