Open AccessConformational transmission in condensed lipid model compounds
Author(s) -
MEULENDIJKS Gijsbert H. W. M.,
HAAN Jan W.,
GENDEREN Marcel H. P.,
BUCK Henk M.
Publication year - 1989
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1989.tb14860.x
Subject(s) - chemistry , magic angle spinning , crystallography , trigonal bipyramidal molecular geometry , conformational change , phospholipid , lipid bilayer , stereochemistry , membrane , nuclear magnetic resonance spectroscopy , crystal structure , biochemistry
On changing the phosphorus coordination from four to five via a trigonal bipyramidal geometry in phospholipid model systems, a conformational change is initated around the C2‐C3 linkage caused by enhanced electrostatic repulsion between the atoms O3 and O2, situated in the axis of the trigonal bipyramid. This is supported by the absence of conformatinal change upon substitution of O2 by methylene. With solid‐state cross‐polarization and magic‐angle spinning 13 C‐NMR it is shown that such a conformational transmission leads to an increased packing density of the lipid chains. It seems to us that changes in lipid packing caused by conformational transmission may also occur when pentacoordination is present transiently, as under biological conditions, thereby inducing an activation of the transport proteins that are embedded in the membrane.