Open AccessAfrican Americans exhibit a predominant allele in the midst of extensive KIR2DL1 allelic diversity
Author(s) -
Hou L.,
Chen M.,
Jiang B.,
Ng J.,
Hurley C. K.
Publication year - 2010
Publication title -
tissue antigens
Language(s) - English
Resource type - Journals
eISSN - 1399-0039
pISSN - 0001-2815
DOI - 10.1111/j.1399-0039.2010.01460.x
Subject(s) - allele , genetics , exon , biology , locus (genetics) , coding region , gene , genomic dna
KIR2DL1 alleles were identified by DNA sequencing of the coding region from amplified genomic DNA from 100 random African Americans. The majority of individuals (97%) carried a KIR2DL1 locus. Allele KIR2DL1*00302 was found in 68% of individuals but KIR2DL1*00401 , *002 , *00303, * 006 , and *007 were also frequent. Eleven new alleles were described: KIR2DL1*00403, *01101, *01102, *012, *013N, *014, *015, *016, *017, *018 , and *019 . Nine of the novel alleles encoded amino acid substitutions located throughout the receptor; one allele carried a stop codon in the exon encoding the first extracellular domain.