Open AccessThe LRC haplotype project: a resource for killer immunoglobulin‐like receptor‐linked association studies
Author(s) -
Horton R.,
Coggill P.,
Miretti M. M.,
Sambrook J. G.,
Traherne J. A.,
Ward R.,
Sims S.,
Palmer S.,
Sehra H.,
Harrow J.,
Rogers J.,
Carrington M.,
Trowsdale J.,
Beck S.
Publication year - 2006
Publication title -
tissue antigens
Language(s) - English
Resource type - Journals
eISSN - 1399-0039
pISSN - 0001-2815
DOI - 10.1111/j.1399-0039.2006.00697.x
Subject(s) - haplotype , major histocompatibility complex , genetics , biology , human leukocyte antigen , haplotype estimation , gene , epistasis , computational biology , allele , antigen
There is increasing evidence for epistatic interactions between gene products (e.g. KIR) encoded within the Leukocyte Receptor Complex (LRC) with those (e.g. HLA) of the Major Histocompatibility Complex (MHC), resulting in susceptibility to disease. Identification of such associations at the DNA level requires comprehensive knowledge of the genetic variation and haplotype structure of the underlying loci. The LRC haplotype project aims to provide this knowledge by sequencing common LRC haplotypes.