Open AccessSulphilimine/Sulfilimine cross‐links in Goodpasture's disease
Author(s) -
Vanacore R.,
Pedchenko V.,
Bhave G.,
Hudson B. G.
Publication year - 2011
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.2011.04356.x
Subject(s) - immunology , goodpasture syndrome , disease , goodpasture's syndrome , biology , medicine , glomerulonephritis , genetics , glomerular basement membrane , pathology , kidney
Summary The sulphilimine/sulfilimine cross‐link of the Goodpasture (GP) autoantigen is a novel molecular mechanism (structural constraint) for conferring immune privilege to a site which otherwise is susceptible to structural changes that induce an immunogenic and pathogenic conformation. Perturbation of the assembly or cleavage of the sulphilimine/sulfilimine cross‐links could be a key factor in the aetiology of Goodpasture's disease in susceptible individuals.