Open AccessHIV‐1 infection of monocyte‐derived macrophages reduces Fc and complement receptor expression
Author(s) -
KENT S. J.,
STENT G.,
SONZA S.,
HUNTER S. D.,
CROWE S. M.
Publication year - 1994
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1994.tb07017.x
Subject(s) - immunology , receptor , flow cytometry , receptor expression , monocyte , immune system , fc receptor , biology , macrophage , pathogenesis , complement receptor , in vitro , complement system , biochemistry
SUMMARY Fc receptor (FcR) and complement receptor (CR) expression on HIV‐infectcd monocyte‐derived macrophages may be an important determinant of immune function. We studied the effects of HI V‐1 infection of macrophages in vitro on FcR and CR expression. Macrophages were infected with HlV‐lpv 7 days following isolation, and the expression of FcgI‐III and CR3 were measured at intervals thereafter by flow cytometry. We found a reduction in receptor expression with the percentage of cells expressing FcRI 14 days post infection declining from 77% to 13%, FcRII fell from 96% to 85%. FcRIII from 45%, to 9%. and CR3 from 91%. to 67& 14 days following infection. As these receptors are important for macrophage function, their down‐modulation muy contribute to the pathogenesis of HIV‐related disease.