Open AccessAntigen presentation by macrophages from bacille Calmette‐Guérin (BCG)‐resistant and ‐susceptible mice
Author(s) -
HILBURGER M. E.,
ZWILLING B. S.
Publication year - 1994
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1994.tb06546.x
Subject(s) - ovalbumin , congenic , antigen , immunology , antigen presentation , biology , major histocompatibility complex , t cell , immune system , biochemistry , gene
SUMMARY We have compared the antigen‐presenting capacity of macrophages from congenic BALB/c.Bcg r and BALB/c.Bcg s mice that differentially express MHC class II glycoproteins. Several different criteria were used to evaluate the presentation of a protein antigen, ovalbumin (OVA), including limiting the concentration of antigen or the numbers of macrophages, and using both native OVA and OVA peptide 323–339. No differences in the capacity of macrophages from Bcg r and Bcg s mice to present antigen to a OVA‐specific T cell hybridoma were found. Splenic macrophages from BCG‐infected congenic mice also induced an equivalent amount of IL‐2 production by the T cell hybridoma. The relationship of these findings to other differences that have been attributed to Bcg are discussed.