Open AccessSignal transduction pathways leading to the production of IL‐8 by human monocytes are differentially regulated by dexamethasone
Author(s) -
ANTTILA H. S. I.,
REITAMO S.,
CESKA M.,
HURME M.
Publication year - 1992
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1992.tb06990.x
Subject(s) - signal transduction , immunology , dexamethasone , biology , microbiology and biotechnology , medicine , endocrinology
SUMMARY Previous studies have shown that IL‐8 gene expression is enhanced by various stimuli, which induce different signal transduction pathways. A lipopolysaccharide (LPS)‐induced pathway has been reported to be inhibited by glucocorticoids in monocytes. We have now examined the effect of dexamethasone on the LPS‐induced and other signal transduction pathways leading to the production of IL‐8 by human monocytes. Dexamethasone Inhibited the production of IL‐8 stimulated with a cyclic adenosine monophosphate analog or LPS. In contrast, dexamethasone had no significant effect on a phorbol ester (PMA)‐stimulated IL‐8 production. These results suggest that the signal transduction pathways leading to the production of IL‐8 by human monocytes are differentially regulated by dexamethasone.