Open AccessIncreased LAK activity against HIV‐infected cell lines in HIV‐1 + individuals
Author(s) -
GRYLLIS C.,
WAINBERG M. A.,
BENTWICH Z.,
GORNITSKY M.,
BRENNER B. G.
Publication year - 1992
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1992.tb06962.x
Subject(s) - lymphokine activated killer cell , immunosurveillance , immunology , biology , virology , cytotoxic t cell , natural killer cell , cellular immunity , virus , major histocompatibility complex , cd8 , immune system , interleukin 21 , in vitro , biochemistry
SUMMARY The role of natural killer (NK) cells and their inducible counterparts, lymphokine‐activated killer (LAK) cells in AIDS with regard to HIV‐1 viral immunosurveillance and the control of secondary opportunistic disease has yet to be established. In this study, we have demonstrated that LAK cells derived from all HIV‐1 + groups showed striking increases in their capacity to lyse HIV‐1‐infected U‐937 cells relative to their uninfected U‐937 counterparts. Surprisingly, similarly derived LAK cells from healthy seronegative controls showed no differences in their lysis of HIV‐1‐infected versus uninfected U‐937 cells. The differential ability of LAK effectors from seropositive donors to lyse HIV‐1‐infected targets was demonstrable using a number of U‐937 subclones and their HIV‐1‐infected counterparts. Again, no differences in LAK cell‐mediated lysis of HIV‐1‐infected and uninfected U‐937 subclones were observed in seronegative individuals. Our findings that HIV‐1 + individuals show selective expansion of non‐MHC restricted. HIV‐1‐directed cytotoxic LAK cells indicate that natural immunity may indeed play a role in HIV‐1 viral immunosurveillance.