Open AccessProlonged clinically asymptomatic evolution after HIV‐1 infection is marked by the absence of complement C4 null alleles at the MHC
Author(s) -
HENTGES F.,
HOFFMANN A.,
ARAUJO F. OLIVEIRA,
HEMMER R.
Publication year - 1992
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1992.tb03067.x
Subject(s) - immunology , allele , asymptomatic , null allele , major histocompatibility complex , biology , complement (music) , complement system , human immunodeficiency virus (hiv) , immune system , virology , genetics , medicine , phenotype , gene , pathology , complementation
SUMMARY The length of time after which persons infected with HIV‐1 progress to AIDS is variable. Certain alleles at the MHC have been shown to influence negatively the clinical outcome of HIV‐1‐infected persons and to be associated with special clinical manifestations. We investigated the MHC class I, class II and class III antigens in 54 Caucasian HIV‐1‐infected persons. The MHC profile of individuals with a prolonged period before AIDS is marked by a lower frequency of C4 null alleles.