Open AccessInhibitory effect of 11 β ‐hydroxypregna‐l,4‐diene‐3,20‐dione (ΔHOP) on lymphocyte proliferation
Author(s) -
RONDI C. M.,
SCHILLACI R.,
CASTILLO M. B.,
ROLDÁN A.
Publication year - 1991
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1991.tb05815.x
Subject(s) - hop (telecommunications) , immunology , t lymphocyte , biology , diene , chemistry , immune system , computer science , telecommunications , natural rubber , organic chemistry
SUMMARY We have compared the immunosuppressive effect of ΔHOP and glucocorticoids on lymphocyte proliferation and IL‐1 secretion. The new synthetic steroid only inhibited proliferation of phytohaemagglutinin (PHA)‐stimulated human lymphocyte at high concentrations and the effect did not persist after washing out the steroid ‐ In contrast, glucocorticoids produced the classical dose‐response inhibition and the effect persisted when they were removed from the cultured medium. Although both steroids decreased IL‐1 secretion from human monocytes stimulated with lipopolysaccharide (LPS), they exert the same effect through a different mechanism. The experiments we report suggest that the decrease of IL‐1 synthesis produced by ΔHOP could be caused by inhibition of LPS phagocytosis. These results support our hypothesis that ΔHOP exerts its immunosuppressive and anti‐inflammatory effect by a non‐genomic mechanism.