Open AccessRaised serum levels of CD8, CD25 and β 2 ‐microglobulin in common variable immunodeficiency
Author(s) -
NORTH M. E.,
SPICKETT G. P.,
WEBSTER A. D. B.,
FARRANT J.
Publication year - 1991
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1991.tb05805.x
Subject(s) - beta 2 microglobulin , common variable immunodeficiency , cd8 , immunology , il 2 receptor , cytokine , tumor necrosis factor alpha , immunodeficiency , antibody , in vitro , biology , medicine , antigen , t cell , immune system , biochemistry
SUMMARY Soluble CD8, soluble CD4, soluble CD25 (IL‐2 receptor), β 2 ‐microglobulin and the cytokine tumour necrosis factor‐alpha (TNF‐α) were measured in sera from patients with common variable immunodeficiency (CVI). Levels of soluble CD8, soluble CD25 and β 2 ‐microglobulin but not of soluble CD4 and TNF‐α were raised significantly above levels in normal sera. Sera from patients with X‐linked agammaglobulinaemia, who are also antibody deficient, did not show this marked elevation. The raised levels of soluble CD8, soluble CD25 and β 2 ‐microglobulin in CVI, correlated with the extent of the defects in the B lymphocytes assessed in vitro , as well as with the clinical severity of the disease. The selective release of these molecules into sera may indicate that abnormal cellular activation occurs in most CVI patients. It is also possible that the raised levels of these soluble molecules play a part in the immunodeficiency.