Open AccessTetrandrine, a plant alkaloid, inhibits the production of tumour necrosis factor‐alpha (cachectin) hy human monocytes
Author(s) -
FERRANTE A.,
SEOW W. K.,
ROWANKELLY B.,
THONG Y. H.
Publication year - 1990
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1990.tb05239.x
Subject(s) - tetrandrine , tumor necrosis factor alpha , peripheral blood mononuclear cell , alkaloid , monocyte , immunology , necrosis , cytokine , staphylococcus aureus , alpha (finance) , biology , medicine , pharmacology , chemistry , in vitro , biochemistry , bacteria , construct validity , nursing , patient satisfaction , botany , genetics
SUMMARY Human mononuclcar leucocytes (MNL) or the adherent fraction (monocytes) produced tumour necrosis factor‐alpha (TNF‐α) (by EL1SA) in culture when stimulated with killed Staphylococcus aureus . The bisbenzylisoquinoline alkaloid, tetrandrine inhibited the capacity of MNL and monocytes to produce TNF‐α at a concentration range of 0·1 to 5 μg/ml. Tetrandrine may be potentially useful in the treatment of inflammatory diseases in which TNF‐α plays a major role.