Open AccessCross‐reactive rheumatoid factors inrheumatoid arthritis with extra‐articular disease
Author(s) -
KINOSHITA M.,
AOTSUKA S.,
YOKOHARI R.
Publication year - 1990
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1990.tb05129.x
Subject(s) - rheumatoid arthritis , immunology , medicine , rheumatoid factor , disease , histone , serology , arthritis , autoantibody , polyclonal antibodies , biology , antibody , dna , genetics
SUMMARY Rheumatoid factors (RF) have been shown to have considerable heterogeneity and bind with IgG aswell as with a variety of substances such as nuclear histone, non‐histone nuclear protein, nitrophenylgroups or ssDNA. We describe evidence that polyclonal RF cross‐reactive with ssDNA (CRRF) arewidely distributed in a variety of rheumatic diseases, and that their serum level is significantly higherin rheumatoid arthritis (RA) with extra‐articular disease. Although the mechanism of the cross‐reactivity is not clear, the presence of CRRF could be a serological feature of a clinical subset of RA.The high prevalence rale of CRRF in RA with extra‐articular disease also suggests its pathogeneticrole in the extra‐articular manifestation of this disease.