Open AccessAnti‐myeloperoxidase antibodies in systemic vasculitis
Author(s) -
LEE S. S.,
ADU D.,
THOMPSON R. A.
Publication year - 1990
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1990.tb05124.x
Subject(s) - immunology , myeloperoxidase , systemic vasculitis , antibody , vasculitis , medicine , systemic disease , biology , immunopathology , inflammation , pathology , disease
SUMMARY Anti‐neutrophil cytoplasmic antibodies (ANCA) are important diagnostic markers in vasculitic disorders. In a study of 164 patients with various clinical syndromes associated with vasculitis, 60 were found to have the antibody, as detected by indirect immunofluorescence; 23 had the so‐called perinuclear antibody pattern, and of these, 15 had antibodies to neutrophil myeloperoxidase in an ELISA. These patients had multi‐system involvement, and 14 of the 15 had histological evidence of small‐vessel arteritis in the kidneys. In preliminary experiments, the isolated IgG from one patient was shown to inhibit luminol‐dependent chemiluminescence of fluid phase myeloperoxidase.