Open AccessHLA‐DR, DQ and T cell antigen receptor constant beta genes in Japanese patients with ulcerative colitis
Author(s) -
KOBAYASHI K.,
ATOH M.,
KONOEDA Y.,
YAGITA A.,
INOKO H.,
SEKIGUCHI S.
Publication year - 1990
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1990.tb03300.x
Subject(s) - ulcerative colitis , antigen , immunology , t cell receptor , human leukocyte antigen , pathogenesis , medicine , beta (programming language) , t cell , immune system , disease , computer science , programming language
SUMMARY We studied the T cell antigen receptor (TcR) constant beta chain genes on HLA typed Japanese patients with ulcerative colitis (UC). A TcR constant beta Eco RI 6.0‐kb fragment was present in all Japanese UC patients ( n= 17) but completely absent in the controls ( n = 35) (x 2 = 47.6, P<0.001). The frequency of HLA‐DR2 antigen was significantly higher in UC patients (85% versus 28% in controls, P <0.001). Furthermore, HLA‐DQwl antigen was also increased in UC patients (96% versus 60% in controls, P <0.001). However, HLA‐DR4 antigen was significantly decreased in UC patients (12% versus 37%, P =0.02). HLA‐DR1 antigen was not found in UC patients and was present in only 15% of the controls. These results suggest that TcR beta chain and HLA‐DQwl antigen may be important in the pathogenesis of Japanese UC.