E uro HYP ‐1: E uropean multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke
Author(s) -
Worp H. Bart,
Macleod Malcolm R.,
Bath Philip M. W.,
Demotes Jacques,
DurandZaleski Isabelle,
Gebhardt Bernd,
Gluud Christian,
Kollmar Rainer,
Krieger Derk W.,
Lees Kennedy R.,
Molina Carlos,
Montaner Joan,
Roine Risto O.,
Petersson Jesper,
Staykov Dimitre,
Szabo Istvan,
Wardlaw Joanna M.,
Schwab Stefan
Publication year - 2014
Publication title -
international journal of stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.375
H-Index - 74
eISSN - 1747-4949
pISSN - 1747-4930
DOI - 10.1111/ijs.12294
Subject(s) - medicine , randomized controlled trial , hypothermia , stroke (engine) , shivering , anesthesia , clinical trial , modified rankin scale , odds ratio , ischemia , ischemic stroke , mechanical engineering , engineering
Cooling reduced infarct size and improved neurological outcomes in animal studies modeling ischemic stroke, and also improved outcome in randomized clinical trials in patients with hypoxic-ischemic brain injury after cardiac arrest. Cooling awake patients with ischemic stroke has been shown feasible in phase II clinical trials.
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