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Body fat, pericardial fat, liver fat and arterial health at age 10 years
Author(s) -
Monasso Giulietta S.,
Santos Susana,
Silva Carolina C. V.,
Geurtsen Madelon L.,
Oei Edwin,
Gaillard Romy,
Felix Janine F.,
Jaddoe Vincent W. V.
Publication year - 2022
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/ijpo.12926
Subject(s) - medicine , obesity , pericardium , cardiology
Summary Background Body mass index is associated with carotid intima‐media thickness and distensibility in adults and children. Objective To examine whether general and specific fat depots are associated with these markers of arterial health at school age. Methods This cross‐sectional analysis was embedded in a population‐based prospective cohort study among 4708 children aged 10 years. Body, lean and fat mass index were estimated by dual‐energy X‐ray absorptiometry. Pericardial, visceral and liver fat were estimated by magnetic resonance imaging. Carotid intima‐media thickness and distensibility were measured by ultrasound. Results A 1‐standard‐deviation‐score (SDS) higher body mass index was associated with higher carotid intima‐media thickness (0.06 SDS, 95% confidence interval [CI]: 0.03–0.08) and lower distensibility (−0.17 SDS, 95% CI: −0.20 to −0.14). These associations tended to be similar for lean mass index. A 1‐SDS higher fat mass index was associated with lower carotid intima‐media thickness (−0.08 SDS, 95% CI: −0.11 to −0.05) and lower distensibility (−0.10 SDS, 95% CI: −0.14 to −0.07). A 1‐SDS higher liver fat fraction was associated with lower carotid intima‐media thickness (−0.04 SDS, 95% CI: −0.08 to −0.00) and lower distensibility (−0.06 SDS, 95% CI: −0.10 to −0.03). We observed similar associations for visceral fat. Conclusions At school age, lean and fat mass seem to be differentially related to carotid intima‐media thickness but not distensibility. Arterial development might be affected by lean mass, general and specific fat mass.