Open AccessRationale, design and preliminary results of the GALIPEMIAS study (prevalence and lipid control of familial dyslipidemia in Galicia, northwest Spain)
Author(s) -
ArgüesoArmesto Rosa María,
PérezCastro TeresaRosalia,
DíazDíaz José Luis,
RodríguezGonzález Avelino,
AmeneirosLago María Eugenia,
AlamoAlonso Alberto,
ToroSantos José Manuel,
FernándezCatalina Pablo Ángel,
PenaSeijo Marta,
DíazPeromingo Jose Antonio,
PoseReino Antonio,
NázaraOtero Carlos Alberto,
VázquezFreire María Rosa,
EscobarSeoane Lisett,
GordoFraile Pedro,
CastellanosRodríguez María del Mar,
RodríguezFernández José Ángel,
Muñiz Javier
Publication year - 2018
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/ijcp.13243
Subject(s) - dyslipidemia , medicine , population , cluster sampling , family history , cross sectional study , risk factor , demography , disease , pediatrics , environmental health , pathology , sociology
Aims There is little information on the familial nature of dyslipidemias in the Spanish population. This knowledge could have potential diagnostic and treatment implications. The objective of the GALIPEMIAS study was to determine the prevalence of familial dyslipidemia in Galicia, as well as determine the degree of lipid control in the participants. Prevalence of atherosclerotic cardiovascular disease ( ASCVD ) was also estimated. This paper presents the design, methodology and selected preliminary results. Methodology A cross‐sectional study was performed in the population aged ≥18 years using cluster sampling and then random sampling. A sample of 1000 subjects was calculated and divided into three sequential phases with a specific methodology for each one. Phase I: selection of subjects from the general population and collection of informed consent documents; Phase II : collection of data from the digital clinical history to select subjects with dyslipidemia according to study criteria; Phase III : personal interview, blood analysis, family tree, and definitive diagnosis of dyslipidemia. Prevalence of different diseases and active medication was analysed. Corrected prevalence (to the reference population) of different risk factors and ASCVD was estimated. Results Phase I participation was 89.5%. We extracted complete information from 93% of the participants (Phase II ). According to the study′s own criteria, 56.5% (n = 527) of the participants had some form of dyslipidemia and almost 33.7% of them had familial dyslipidemia with autosomal dominant inherit pattern. The corrected prevalence of ASCVD was 5.1% (95% CI 3.1‐7.2). Conclusions Dyslipidemia was the most prevalent cardiovascular risk factor in our population with an autosomal dominant inheritance pattern in one out of every three dyslipidemia cases. Approximately, 5.1% of the sample population aged ≥18 has suffered an episode of ACVD .