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Immature acute leukaemias: lessons from the haematopoietic roadmap
Author(s) -
Lefeivre Thomas,
Jones Luke,
Trinquand Amélie,
Pinton Antoine,
Macintyre Elizabeth,
Laurenti Elisa,
Bond Jonathan
Publication year - 2022
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.16030
Subject(s) - haematopoiesis , myeloid , blood cancer , immunology , myeloid leukaemia , biology , medicine , cancer , cancer research , stem cell , microbiology and biotechnology
It is essential to relate the biology of acute leukaemia to normal blood cell development. In this review, we discuss how modern models of haematopoiesis might inform approaches to diagnosis and management of immature leukaemias, with a specific focus on T‐lymphoid and myeloid cases. In particular, we consider whether next‐generation analytical tools could provide new perspectives that could improve our understanding of immature blood cancer biology.