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Association between serum secretory phospholipase A2 and risk of ischaemic stroke
Author(s) -
Smith Jed W.,
Barlas Raphae S.,
Mamas Mamas A.,
Boekholdt S. Matthijs,
Mallat Ziad,
Luben Robert N.,
Wareham Nicholas J.,
Khaw KayTee,
Myint Phyo K.
Publication year - 2021
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.15004
Subject(s) - medicine , odds ratio , ischaemic stroke , confounding , stroke (engine) , logistic regression , confidence interval , prospective cohort study , case control study , nested case control study , ischemia , mechanical engineering , engineering
Background and purpose Previous literature has demonstrated an association between high serum levels of type II secretory phospholipase A2 (sPLA2) concentration and an increased risk of coronary artery disease. However, such association has not been established in terms of ischaemic stroke risk. The aim was to evaluate the association between both sPLA2 concentration and activity as continuous variables with risk of future ischaemic stroke. Methods A nested case–control study was conducted using data from the European Prospective Investigation into Cancer—Norfolk study. Cases ( n = 145) in the current study were participants who developed ischaemic stroke during follow‐up, with controls ( n = 290) matched in a 2:1 ratio based on age and sex. Statistical analyses were performed using SPSS (version 25.0) software. Logistic regression was used to determine odds ratios (OR) and corresponding 95% confidence intervals (95% CIs) for ischaemic stroke. Results After adjusting for a wide array of cardiovascular confounders, sPLA2 activity was found to be associated with an increased risk of ischaemic stroke using both multiple imputations with chained equations and complete case analysis: OR 1.20 (95% CI 1.01–1.43) and OR 1.23 (95% CI 1.01−1.49), respectively. However, sPLA2 concentration was not found to be associated with increased risk of ischaemic stroke. Conclusions The activity of sPLA2, but not sPLA2 concentration, is associated with an increased risk of future ischaemic stroke. This finding may be significant in risk group stratification, allowing targeted prophylactic treatment, or the development of novel therapeutic agents.