Open AccessFibroblast Senescence and Squamous Cell Carcinoma: How Wounding Therapies Could Be Protective
Author(s) -
Travers Jeffrey B.,
Spandau Dan F,
Lewis Davina A.,
Machado Christiane,
Kingsley Melanie,
Mousdicas Nico,
Somani AllyKhan
Publication year - 2013
Publication title -
dermatologic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.659
H-Index - 125
eISSN - 1524-4725
pISSN - 1076-0512
DOI - 10.1111/dsu.12138
Subject(s) - medicine , dermis , skin aging , cancer research , dermabrasion , dermal fibroblast , fibroblast , rejuvenation , dermatology , senescence , cancer , premature aging , oncology , pathology , biology , gerontology , cell culture , physiology , genetics
Background Squamous cell carcinoma ( SCC ), which has one of the highest incidences of all cancers in the U nited S tates, is an age‐dependent disease, with the majority of these cancers diagnosed in people age 70 and older. Recent findings have led to a new hypothesis on the pathogenesis of SCC . Objectives To evaluate the potential of preventive therapies to reduce the incidence of SCC in at‐risk geriatric patients. Materials and Methods Survey of current literature on wounding therapies to prevent SCC s. Results This new hypothesis of SCC photocarcinogenesis states that senescent fibroblasts accumulate in the dermis, resulting in a reduction in dermal insulin‐like growth factor‐1 ( IGF ‐1) expression. This lack of IGF ‐1 expression sensitizes epidermal keratinocytes to fail to suppress ultraviolet light B ( UVB )‐induced mutations, leading to increased proclivity to photocarcinogenesis. Recent evidence suggests that dermal wounding therapies, specifically dermabrasion and fractionated laser resurfacing, can decrease the proportion of senescent dermal fibroblasts, increase dermal IGF ‐1 expression, and correct the inappropriate UVB response found in geriatric skin, protecting geriatric keratinocytes from UVB ‐induced SCC initiation. Conclusions In this review, we will discuss the translation of pioneering basic science results implicating commonly used dermal fibroblast rejuvenation procedures as preventative treatments for SCC .