Open AccessBirthplace and esophageal cancer incidence patterns among A sian‐ A mericans
Author(s) -
Kim J. Y.,
Winters J. K.,
Kim J.,
Bernstein L.,
Raz D.,
Gomez S. L.
Publication year - 2016
Publication title -
diseases of the esophagus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.115
H-Index - 63
eISSN - 1442-2050
pISSN - 1120-8694
DOI - 10.1111/dote.12302
Subject(s) - medicine , adenocarcinoma , incidence (geometry) , esophageal cancer , population , demography , cancer , asian americans , carcinoma , ethnic group , oncology , environmental health , physics , sociology , anthropology , optics
Summary The incidence of esophageal adenocarcinoma in the U nited S tates has risen rapidly over the last 30 years, whereas the incidence of esophageal squamous cell carcinoma has fallen dramatically. In contrast, parts of A sia have extremely high rates of squamous cell carcinoma, but virtually no adenocarcinoma. Within the U nited S tates, A sian‐ A mericans as a whole, have low rates of esophageal adenocarcinoma and higher rates of squamous cell carcinoma. It is unclear what the patterns are for those A sians born in the U nited S tates. The relative influence of ethnicity and environment on the incidence of esophageal cancer in this population is unknown. We identified all cases of esophageal adenocarcinoma and squamous cell carcinoma from the C alifornia C ancer R egistry 1988–2004, including 955 cases among 6 different A sian ethnicities. Time trends were examined using J oinpoint software to calculate the annual percentage changes in regression models. Rates of esophageal squamous cell carcinoma varied substantially among different A sian ethnic groups, but squamous cell carcinoma was much more common than adenocarcinoma in both foreign‐born and US ‐born A sian‐ A mericans. Rates of squamous cell carcinoma were slightly higher among US ‐born A sian men (4.0 per 100,000) compared with foreign‐born A sian men (3.2 per 100,000) and W hite men (2.2 per 100,000), P = 0.03. Rates of adenocarcinoma were also slighter higher among US ‐born A sian men (1.2 per 100,000) compared with foreign‐born A sian men (0.7 per 100,000), P = 0.01. Rates of squamous cell carcinoma decreased for both US ‐born and foreign‐born A sians during this period, whereas adenocarcinoma remained low and stable. These results provide better insight into the genetic and environmental factors affecting the changing incidence of esophageal cancer histologies in the U nited S tates and A sia.