Open AccessInterleukin 12 B rs3212227 T > G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma in a C hinese population
Author(s) -
Yin J.,
Wang X.,
Wei J.,
Wang L.,
Shi Y.,
Zheng L.,
Tang W.,
Ding G.,
Liu C.,
Liu R.,
Chen S.,
Xu Z.,
Gu H.
Publication year - 2015
Publication title -
diseases of the esophagus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.115
H-Index - 63
eISSN - 1442-2050
pISSN - 1120-8694
DOI - 10.1111/dote.12189
Subject(s) - single nucleotide polymorphism , genotype , polymorphism (computer science) , medicine , bioinformatics , oncology , gene , biology , genetics
Summary Gastric cardiac adenocarcinoma ( GCA ) is one of common malignant tumors in the world. Multiple genes that play critical roles in inflammatory pathways probably are associated with GCA risk. We conducted a hospital‐based case–control study to evaluate the genetic effects of functional single nucleotide polymorphisms ( SNPs ): interleukin 9 ( IL 9) rs31563 C > T , IL 9 rs31564 G > T , IL 10 rs1800872 T > G , IL 12 A rs2243115 T > G , IL 12 B rs3212227 T > G , and IL 13 rs1800925 C > T on the development of GCA . Two hundred and forty‐three GCA cases and 476 controls were recruited. Their genotypes were determined using a custom‐by‐design 48‐ P lex SNPscan kit. IL 12 B rs3212227 T > G polymorphism was associated with the increased risk of GCA . However, there was no significant association between the other five SNPs and GCA risk. Stratified analyses indicated that the risk of GCA associated with the IL 12 B rs3212227 T > G polymorphism was evident among female patients and patients who never smoked or consumed alcoholic drinks. These findings indicated that functional polymorphism IL 12 B rs3212227 T > G might correlate with GCA risk. However, our results were obtained with a limited sample size; the power of our analysis was low. Larger studies are required to confirm the current findings.