Open AccessAltered dynamic functional network connectivity in levodopa‐induced dyskinesia of Parkinson's disease
Author(s) -
Si Qianqian,
Gan Caiting,
Zhang Heng,
Cao Xingyue,
Sun Huimin,
Wang Min,
Wang Lina,
Yuan Yongsheng,
Zhang Kezhong
Publication year - 2023
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.13994
Subject(s) - dyskinesia , parkinson's disease , levodopa , neuroscience , resting state fmri , psychology , medicine , physical medicine and rehabilitation , disease
Aims The aim of this study was to clarify the dynamic neural activity of levodopa‐induced dyskinesia (LID) in Parkinson's disease (PD). Methods Using dynamic functional network connectivity (dFNC) analysis, we evaluated 41 PD patients with LID (LID group) and 34 PD patients without LID (No‐LID group). Group spatial independent component analysis and sliding‐window approach were employed. Moreover, we applied a k‐means clustering algorithm on windowed functional connectivity (FC) matrices to identify reoccurring FC patterns (i.e., states). Results The optimal number of states was determined to be five, the so‐called State 1, 2, 3, 4, and 5. In ON phase, compared with No‐LID group, LID group occurred more frequently and dwelled longer in strongly connected State 1, characterized by strong positive connections between visual network (VIS) and sensorimotor network (SMN). When switching from OFF to ON phase, LID group occurred less frequently in State 3 and State 4. Meanwhile, LID group dwelled longer in State 2 and shorter in State 3. No‐LID group occurred more frequently in State 5 and less frequently in State 3. Additionally, correlation analysis demonstrated that dyskinesia's severity was associated with frequency of occurrence and dwell time in State 2, dominated by inferior frontal cortex in cognitive executive network (CEN). Conclusion Using dFNC analysis, we found that dyskinesia may be related to the dysfunctional inhibition of CEN on motor loops and excessive excitation of VIS and SMN, which provided evidence of the changes in brain dynamics associated with the occurrence of dyskinesia.