Open AccessCellular M icrobiology: The metabolic interface between host cell and pathogen
Author(s) -
Russell David G.
Publication year - 2019
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/cmi.13075
Subject(s) - biology , host (biology) , pathogen , microbiology and biotechnology , cell culture , cell , perspective (graphical) , computational biology , in vivo , genetics , artificial intelligence , computer science
Cellular Microbiology has benefited greatly from the use of immortalized cell lines as host cells for tissue culture models of infection. However, these cells lack many important characteristics of the different cell lineages that are found in vivo. This deficiency is particularly true of macrophages that we now know derive from several distinct ontogenic lineages. This perspective discusses these challenges and possible approaches to overcome them.