Open AccessLipid interactions during virus entry and infection
Author(s) -
Mazzon Michela,
Mercer Jason
Publication year - 2014
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/cmi.12340
Subject(s) - biology , lipid metabolism , compartmentalization (fire protection) , viral entry , host (biology) , microbiology and biotechnology , lipid raft , virus , lipid signaling , signalling , computational biology , virology , viral replication , immunology , signal transduction , genetics , inflammation , biochemistry , enzyme
Summary For entry and infection viruses have developed numerous strategies to subjugate indispensable cellular factors and functions. Host cell lipids and cellular lipid synthesis machinery are no exception. Not only do viruses exploit existing lipid signalling and modifications for virus entry and trafficking, they also reprogram lipid synthesis, metabolism, and compartmentalization for assembly and egress. Here we review these various concepts and highlight recent progress in understanding viral interactions with host cell lipids during entry and assembly.