Open AccessSignalling C ‐Type lectin receptors, microbial recognition and immunity
Author(s) -
Hoving J. Claire,
Wilson Gillian J.,
Brown Gordon D.
Publication year - 2014
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/cmi.12249
Subject(s) - c type lectin , biology , pattern recognition receptor , immune system , immunity , receptor , immunology , microbiology and biotechnology , lectin , biochemistry
Summary Signalling C ‐type lectin receptors ( CLR s) are crucial in shaping the immune response to fungal pathogens, but comparably little is known about the role of these receptors in bacterial, viral and parasitic infections. CLR s have many diverse functions depending on the signalling motifs in their cytoplasmic domains, and can induce endocytic, phagocytic, antimicrobial, pro‐inflammatory or anti‐inflammatory responses which are either protective or not during an infection. Understanding the role of CLR s in shaping anti‐microbial immunity offers great potential for the future development of therapeutics for disease intervention. In this review we will focus on the recognition of bacterial, viral and parasitic pathogens by CLR s, and how these receptors influence the outcome of infection. We will also provide a brief update on the role of CLR s in antifungal immunity.