Open AccessFAM96A knock‐out promotes alternative macrophage polarization and protects mice against sepsis
Author(s) -
Yin A.,
Chen W.,
Cao L.,
Li Q.,
Zhu X.,
Wang L.
Publication year - 2021
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/cei.13555
Subject(s) - sepsis , proinflammatory cytokine , immunology , immune system , biology , macrophage polarization , lipopolysaccharide , macrophage , adoptive cell transfer , inflammation , cancer research , t cell , in vitro , biochemistry
FAM96A knockout protects against organ damage from sepsis and significantly prolongs survival because of reduced secretion of pro‐inflammatory cytokines by macrophages. FAM96A affects the OXPHOS‐glycolysis shifting (Warburg effect) during macrophage transformation.
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