Protease inhibitors elicit anti‐inflammatory effects in CF mice with  Pseudomonas aeruginosa  acute lung infection | Zendy

Sandri A. | Zendy; Lleo M. M. | Zendy; Signoretto C. | Zendy; Boaretti M. | Zendy; Boschi F. | Zendy

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Protease inhibitors elicit anti‐inflammatory effects in CF mice with Pseudomonas aeruginosa acute lung infection

Author(s) -

Sandri A.,

Lleo M. M.,

Signoretto C.,

Boaretti M.,

Boschi F.

Publication year - 2021

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/cei.13518

Subject(s) - cystic fibrosis , proteases , pseudomonas aeruginosa , bioluminescence imaging , cystic fibrosis transmembrane conductance regulator , protease , biology , lung , immunology , inflammation , microbiology and biotechnology , medicine , enzyme , luciferase , cell culture , biochemistry , bacteria , transfection , genetics

Secretion of bacterial and host proteases in the lungs of CF patients strongly contribute to exacerbation of the inflammatory response and lung damage. Local treatment with matrix metalloprotease inhibitors Marimastat and Ilomastat can reduce the IL‐8‐mediated lung inflammation induced by Pseudomonas aeruginosa acute lung infection in CF mice.

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