Premium
The role of FoxO1 and its modulation with small molecules in the development of diabetes mellitus: A review
Author(s) -
Nathanael Joshua,
Suardana Putu,
Vianney Yoanes Maria,
Dwi Putra Sulistyo Emantoko
Publication year - 2022
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.13989
Subject(s) - foxo1 , insulin resistance , diabetes mellitus , type 2 diabetes mellitus , insulin , type 2 diabetes , downregulation and upregulation , review article , oxidative stress , bioinformatics , biology , medicine , gene , endocrinology , transcription factor , genetics , pathology
Diabetes mellitus type 2 (T2D) is one of the metabolic disorders suffered by a global human being. Certain factors, such as lifestyle and heredity, can increase a person's tendency for T2D. Various genes and proteins play a role in the development of insulin resistance and ultimately diabetes in which one central protein that is discussed in this review is FoxO1. In this review, we regard FoxO1 activation as detrimental, promote high plasma glucose level, and induce insulin resistance. Indeed, many contrasting studies arise since FoxO1 is an important protein to alleviate oxidative stress and promote cell survival, for example, also by preventing hyperglycemic‐induced cell death. Inter‐relation to PPARG, another important protein in metabolism, is also discussed. Ultimately, we discussed contrasting approaches of targeting FoxO1 to combat diabetes mellitus by small molecules.