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Pharmacokinetics of 2 oral paracetamol formulations in hospitalized octogenarians
Author(s) -
Hias Julie,
Van der Linden Lorenz,
Walgraeve Karolien,
Gijsen Matthias,
Mian Paola,
Koch Birgit C. P.,
Allegaert Karel,
Annaert Pieter,
Tournoy Jos,
Spriet Isabel
Publication year - 2022
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.15049
Subject(s) - pharmacokinetics , medicine , dosing , interquartile range , analgesic , bioequivalence , acetaminophen , trough concentration , pharmacology
Aims It is currently unclear how paracetamol should be dosed in order to increase its efficacy while warranting safety in very old adults. The objective was to evaluate the pharmacokinetics of 2 oral paracetamol formulations and its metabolites in hospitalized octogenarians. Methods Geriatric inpatients aged 80 years and older received a 1000‐mg paracetamol tablet or granulate at 08.00, 14.00 and 20.00. After at least 4 consecutive gifts, plasma samples were collected around the 08.00 dose (trough, +0.5, +1, +2, +4, +5 and +6 h). Plasma concentrations of paracetamol and its metabolites were determined and individual pharmacokinetic parameters were derived. The Edmonton Frail Scale was used to assess frailty. An analgesic plasma target was defined as an average plasma concentration (C avg ) of 10 mg/L. Results The mean (±standard deviation) age was 86.78 (±4.20) years. The majority ( n = 26/36, 72%) received the tablet, 10 (28%) the granulate. Thirty patients (85%) were classified with moderate to severe frailty. Seven (21%) patients had a C avg above 10 mg/L. The median [interquartile range] time to reach the peak concentration was 50.5 [31.50–92.50] and 42.50 [33.75–106.75] min for the tablet and granulate, respectively. The coefficient of variation was 95% for time to reach the peak concentration and 30% for C avg of paracetamol. A correlation of C avg of paracetamol was observed with female sex and total serum bilirubin. Conclusion Large interindividual differences were found for pharmacokinetic parameters of oral paracetamol in frail inpatients after multiple dosing. Female sex and higher total serum bilirubin concentrations were associated with paracetamol exposure. No significant differences were observed between the tablet and granulate.