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The impact of androgen deprivation therapy on bone mineral density in men treated for paraphilic disorder: A retrospective cohort study
Author(s) -
De Landtsheer Anaïs,
Bekaert Lieslinde,
David Karel,
Marcq Philippe,
Jeandarme Inge,
Decallonne Brigitte,
Antonio Leen,
Vanderschueren Dirk
Publication year - 2022
Publication title -
andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 43
eISSN - 2047-2927
pISSN - 2047-2919
DOI - 10.1111/andr.13142
Subject(s) - medicine , bone mineral , femoral neck , androgen deprivation therapy , urology , cohort , femur , bone density , osteoporosis , endocrinology , prostate cancer , surgery , cancer
Background Guidelines suggest treating men with paraphilic disorder with androgen‐deprivation therapy (ADT). However, little evidence is available about the long‐term impact on bone loss and how to manage this adverse event. Objectives The aim of this study is to assess the impact of ADT on bone mineral density (BMD) in men treated for paraphilic disorder with the androgen receptor blocker cyproterone acetate (CPA) and/or GnRH agonist triptoreline (GnRHa) and to evaluate the effect of treatment with bisphosphonates. Methods Baseline and follow‐up dual‐energy X‐ray absorptiometry scan (DXA‐scan) data (lumbar and femoral T‐scores) were retrospectively extracted from electronic medical files of paraphilic men who received CPA and/or GnRHa. Results A total of 53 patients with a mean age of 39.1 years (range 17.5–74.6) were included. Lumbar (−0.39 ± 0.17, Mean ± SEM, p = 0.046), femoral neck (−0.34 ± 0.09, p = 0.002) and total femur (−0.33 ± 0.12, p = 0.014) T‐scores decreased significantly in the CPA‐only group ( n = 13) during a mean follow‐up of 6.0 ± 5.3 years. In the GnRHa group ( n = 29), T‐scores at all sites decreased significantly over 6.6 ± 4.4 years (lumbar: −0.55 ± 0.12, p < 0.001, femoral neck: −0.53 ± 0.09, total femur: −0.44 ± 0.09, p < 0.001). In the group, who received bisphosphonates ( n = 11), no significant T‐score change was observed (lumbar: −0.25 ± 0.14, p = 0.106, femoral neck −0.15 ± 0.17, p = 0.402, total femur −0.25 ± 0.14, p = 0.106) during 5.0 ± 2.8 years of follow‐up. Discussion and conclusion Following a mean duration of 6 years of ADT, we observed a significant decline in BMD of approximately half a standard deviation in T‐score at lumbar and femoral site. Although the number of patients who received bisphosphonates was limited, this treatment seems to have a positive stabilizing effect on bone density.