Open AccessResistance to the quorum‐quenching compounds brominated furanone C‐30 and 5‐fluorouracil in P seudomonas aeruginosa clinical isolates
Author(s) -
GarcíaContreras Rodolfo,
MartínezVázquez Mariano,
Velázquez Guadarrama Norma,
Villegas Pañeda Alejandra Guadalupe,
Hashimoto Takahiro,
Maeda Toshinari,
Quezada Héctor,
Wood Thomas K.
Publication year - 2013
Publication title -
pathogens and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.983
H-Index - 105
ISSN - 2049-632X
DOI - 10.1111/2049-632x.12039
Subject(s) - pyocyanin , quorum quenching , pseudomonas aeruginosa , microbiology and biotechnology , quorum sensing , fluorouracil , elastase , biology , chemistry , bacteria , biochemistry , biofilm , enzyme , genetics , chemotherapy
The quorum‐quenching compounds brominated furanone C‐30 and 5‐fluorouracil inhibit the pathogenicity of the P seudomonas aeruginosa laboratory strains PA 01 and PA 14; however, there is no report studying the effectiveness of these compounds for clinical isolates. Therefore, the effect of both quorum quenchers on the production of pyocyanin, elastase and alkaline protease of eight clinical strains from children was evaluated. Although both compounds were in general effective for the attenuation of these factors, three strains resistant to C‐30 were found. For 5‐fluorouracil, PA 01 and some clinical isolates showed resistance for at least one phenotype.