Open AccessB ordetella holmesii : initial genomic analysis of an emerging opportunist
Author(s) -
Planet Paul J.,
Narechania Apurva,
Hymes Saul R.,
Gagliardo Christina,
Huard Richard C.,
Whittier Susan,
DellaLatta Phyllis,
Ratner Adam J.
Publication year - 2013
Publication title -
pathogens and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.983
H-Index - 105
ISSN - 2049-632X
DOI - 10.1111/2049-632x.12028
Subject(s) - locus (genetics) , bordetella , virulence , bacteremia , pathogen , biology , opportunistic pathogen , genome , microbiology and biotechnology , medicine , genetics , gene , bacteria , bordetella pertussis , antibiotics
B ordetella holmesii is an emerging opportunistic pathogen that causes respiratory disease in healthy individuals and invasive infections among patients lacking splenic function. We used 16 S r RNA gene analysis to confirm B . holmesii as the cause of bacteremia in a child with sickle cell disease. Semiconductor‐based draft genome sequencing provided insight into B . holmesii phylogeny and potential virulence mechanisms and also identified a toluene‐4‐monoxygenase locus unique among bordetellae.