Open AccessAlterations of penicillin‐binding proteins in pneumococci with stepwise increase in β‐lactam resistance
Author(s) -
Hsieh YuChia,
Su LinHui,
Hsu MeiHua,
Chiu ChengHsun
Publication year - 2013
Publication title -
pathogens and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.983
H-Index - 105
ISSN - 2049-632X
DOI - 10.1111/2049-632x.12018
Subject(s) - streptococcus pneumoniae , penicillin , penicillin binding proteins , microbiology and biotechnology , pneumococcal infections , lactam , ceftriaxone , penicillin resistance , streptococcaceae , population , biology , cephalosporin , antibiotics , chemistry , medicine , environmental health , stereochemistry
Infection caused by S treptococcus pneumoniae has become increasingly complicated and costly to treat due to the increase in β‐lactam resistance. A total of 80 pneumococcal isolates with stepwise increase in penicillin and ceftriaxone resistance were analyzed for the sequential changes in their penicillin‐binding proteins ( PBP s) 1a, 2b, and 2x. The result provides an insight into the evolution of PBP s associated with β‐lactam resistance in a natural population of S . pneumoniae .