Open AccessMultiple invasion mechanisms and different intracellular Behaviors: a new vision of Salmonella –host cell interaction
Author(s) -
Boumart Zineb,
Velge Philippe,
Wiedemann Agnès
Publication year - 2014
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/1574-6968.12614
Subject(s) - salmonella , biology , intracellular parasite , intracellular , microbiology and biotechnology , secretion , type three secretion system , vacuole , cytosol , bacteria , cell , cytoplasm , virulence , genetics , gene , biochemistry , enzyme
Salmonella is a facultative intracellular bacterium found within a variety of phagocytic and nonphagocytic cells in vitro and in vivo . For decades, it has been accepted that Salmonella can enter cells only through a Trigger mechanism mediated by a type three secretion system, called T3 SS ‐1. However, recent researches have shown that this bacterium can use other invasion pathways mediating either Trigger or Zipper entry processes. Following eukaryotic cell invasion, Salmonella has to ensure its survival and proliferation within host cells. To do so, this bacterium resides either within a membrane‐bound vacuole or freely within host cell cytosol. It is not clear why Salmonella has developed these alternate mechanisms for cell invasion and proliferation, but this provides a new insight into the mechanisms leading to Salmonella‐ induced diseases. Thus, the aim of this review is to show the evolution of Salmonella –host cell interaction paradigms by summarizing the different strategies used by Salmonella serotypes to invade and proliferate into eukaryotic cells.