Open AccessOxygen distribution in proteins defines functional significance of the genome and proteome of the malaria parasite P lasmodium falciparum 3 D 7
Author(s) -
Palanisamy Balamurugan,
Heese Klaus
Publication year - 2014
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/1574-6968.12355
Subject(s) - proteome , plasmodium falciparum , biology , malaria , genome , computational biology , plasmodium (life cycle) , function (biology) , parasite hosting , genetics , virology , gene , immunology , world wide web , computer science
Although G laxo S mith K line is on the way to launch the new vaccine candidate ‘ RTS , S ’, the search for suitable antimalarial drugs still remains an exceeding challenge because P lasmodium falciparum ‐mediated malaria is one of the most lethal diseases in the world. Novel innovative ideas are required to identify new potential molecular targets to be able to fight this lethal parasite efficiently. We used an unconventional bioinformatics approach to analyze the entire genome and proteome of the P f 3 D 7 strain. Because the oxygen ( O ‐) content is a decisive parameter that determines the function of a protein, we analyzed the entire P f 3 D 7 proteome based on O ‐containing amino acid expression. Our data disclose a total of four proteins encoded by chromosome ( C hr)‐4 and C hr‐9 that have an outstanding O ‐controlled character. The identification of the biological significance of these proteins could eventually lead to new vital drug targets.