Open AccessApproaches to study yeast cell aging and death
Author(s) -
Mirisola Mario G.,
Braun Ralf J.,
Petranovic Dina
Publication year - 2014
Publication title -
fems yeast research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 92
eISSN - 1567-1364
pISSN - 1567-1356
DOI - 10.1111/1567-1364.12112
Subject(s) - yeast , biology , model organism , organism , calorie restriction , programmed cell death , saccharomyces cerevisiae , cell survival , cell , computational biology , genetics , apoptosis , gene , endocrinology
For millennia, yeast has been exploited to obtain fermentation products, such as foods and beverages. For c . 50 years, yeast has been an established model organism for basic and applied research, and more specifically, for c . 15 years, this unicellular organism has been applied to dissect molecular mechanisms of cell aging and programmed cell death. In this review, we present an overview of approaches to study cell aging and death in yeast, including lifespan assessments, calorie restriction, cell viability, survival, and death markers.