Open AccessProtein quality control in time and space – links to cellular aging
Author(s) -
Nyström Thomas,
Liu Beidong
Publication year - 2014
Publication title -
fems yeast research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 92
eISSN - 1567-1364
pISSN - 1567-1356
DOI - 10.1111/1567-1364.12095
Subject(s) - biology , multicellular organism , budding yeast , soma , saccharomyces cerevisiae , yeast , lineage (genetic) , inheritance (genetic algorithm) , genetics , evolutionary biology , budding , population , gene , demography , neuroscience , sociology
The evolutionary theory of aging regards aging as an evolved characteristic of the soma, and proponents of the theory state that selection does not allow the evolution of aging in unicellular species lacking a soma–germ demarcation. However, the life history of some microorganisms, reproducing vegetatively by either budding or binary fission, has been demonstrated to encompass an ordered, polar‐dependent, segregation of damage leading to an aging cell lineage within the clonal population. In the yeast S accharomyces cerevisiae and the bacterium E scherichia coli, such segregation is under genetic control and includes an asymmetrical inheritance of protein aggregates and inclusions. Herein, the ultimate and proximate causation for such an asymmetrical inheritance, with special emphasis on damaged/aggregated proteins in budding yeast, is reviewed.