Open Accessp53 death signal is mainly mediated by N uc1( E ndo G ) in the yeast S accharomyces cerevisiae
Author(s) -
Palermo Vanessa,
Mangiapelo Eleonora,
Piloto Cristina,
Pieri Luisa,
Muscolini Michela,
Tuosto Loretta,
Mazzoni Cristina
Publication year - 2013
Publication title -
fems yeast research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 92
eISSN - 1567-1364
pISSN - 1567-1356
DOI - 10.1111/1567-1364.12067
Subject(s) - saccharomyces cerevisiae , biology , yeast , apoptosis , programmed cell death , microbiology and biotechnology , mutant , suppressor , stimulus (psychology) , cell , genetics , gene , psychology , psychotherapist
The tumor suppressor p53 plays a central role in the regulation of cellular growth and apoptosis. In the yeast S accharomyces cerevisiae , the overexpression of the human p53 leads to growth inhibition and apoptotic cell death on minimal medium. In the present work, we show that p53‐expressing cells are more susceptible to cell death after an apoptotic stimulus such as H 2 O 2 . The analysis of mutants involved in yeast apoptosis‐like death suggests that the observed cell death is Y ca1 independent and mainly mediated through N uc1p.