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We present a concept for integrating focused ultrasound (FUS) with electrophysiological neuroimaging, in order to achieve high spatiotemporal resolution brain imaging. This approach, which we are tentatively calling acousto-electrophysiological neuroimaging, leverages on the spatial focality and noninvasiveness of FUS and may potentially lead to a noninvasive human brain imaging modality with high resolution in both space and time domains. By the use of modulated FUS, spatial selectivity can be accomplished for high-resolution electrophysiological neuroimaging. Frequency shifting in resulting magnetic signals (using modulated FUS) may potentially open the door for a room temperature magnetoencephalography device.

Focused Ultrasound Help Realize High Spatiotemporal Brain Imaging? - A Concept on Acousto-Electrophysiological Neuroimaging