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Single‐crystal‐to‐single‐crystal phase transition of 18β‐glycyrrhetinic acid isopropyl ester
Author(s) -
Langer Dominik,
Wicher Barbara,
Tykarska Ewa
Publication year - 2022
Publication title -
acta crystallographica section b
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.604
H-Index - 33
ISSN - 2052-5206
DOI - 10.1107/s2052520622002517
Subject(s) - isostructural , isopropyl , single crystal , chemistry , phase transition , substituent , crystal (programming language) , crystallography , crystal structure , phase (matter) , stereochemistry , organic chemistry , materials science , thermodynamics , programming language , physics , computer science
Due to the destruction of the integrity of the parent crystal, single‐crystal‐to‐single‐crystal phase transition in organic compounds is still a relatively rare phenomenon. The phase transition in glycyrrhetinic acid isopropyl ester is triggered by temperature change. The increasing volume of the isopropyl substituent as a result of increasing temperature forces a remodelling of the structural motifs. These changes cause a single‐crystal‐to‐single‐crystal phase transition. The low‐temperature form is isostructural with glycyrrhetinic acid methanol solvate, while the high‐temperature phase is isostructural with the ethyl ester of this acid.