Open AccessStructure of AKR1C3 with 3‐phenoxybenzoic acid bound
Author(s) -
Jackson Victoria J.,
Yosaatmadja Yuliana,
Flanagan Jack U.,
Squire Christopher J.
Publication year - 2012
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
ISSN - 1744-3091
DOI - 10.1107/s1744309112009049
Subject(s) - nonsteroidal , enzyme , aldo keto reductase , reductase , oxidoreductase , drug , chemistry , biology , biochemistry , cancer research , pharmacology
Aldo–keto reductase 1C3 (AKR1C3) is a human enzyme that catalyzes the NADPH‐dependent reduction of steroids and prostaglandins. AKR1C3 overexpression is associated with the proliferation of hormone‐dependent cancers, most notably breast and prostate cancers. Nonsteroidal anti‐inflammatory drugs (NSAIDs) and their analogues are well characterized inhibitors of AKR1C3. Here, the X‐ray crystal structure of 3‐phenoxybenzoic acid in complex with AKR1C3 is presented. This structure provides useful information for the future development of new anticancer agents by structure‐guided drug design.