Open AccessStructure of New Delhi metallo‐β‐lactamase 1 (NDM‐1)
Author(s) -
Green Victoria L.,
Verma Anil,
Owens Raymond J.,
Phillips Simon E. V.,
Carr Stephen B.
Publication year - 2011
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
ISSN - 1744-3091
DOI - 10.1107/s1744309111029654
Subject(s) - klebsiella pneumoniae , new delhi , context (archaeology) , microbiology and biotechnology , antibiotic resistance , antibiotics , biology , multiple drug resistance , genetics , medicine , escherichia coli , gene , pathology , paleontology , metropolitan area
Antibiotic resistance in bacterial pathogens poses a serious threat to human health and the metallo‐β‐lactamase (MBL) enzymes are responsible for much of this resistance. The recently identified New Delhi MBL 1 (NDM‐1) is a novel member of this family that is capable of hydrolysing a wide variety of clinically important antibiotics. Here, the crystal structure of NDM‐1 from Klebsiella pneumoniae is reported and its structure and active site are discussed in the context of other recently deposited coordinates of NDM‐1.